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8_multiple_testing.do
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8_multiple_testing.do
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/*------------------------------------------------------------------------------
------------------------------------------------------------------------------
* Project: GxE using NTR
* Authors: Ghirardi et al. (2024)
* Dofile topic: Romano-Wolf correction
------------------------------------------------------------------------------
------------------------------------------------------------------------------*/
* More info: rwolf2 = https://www.damianclarke.net/computation/rwolf2.pdf
//ssc install rwolf2, replace
********************************************************************************
* Datasets construction:
// to have only one dataset for every outcome, we take the datasets we have
// before creating one dataset for each outcome (see 4_samples_ALL)
********************************************************************************
* ---------------------------------------------------------------------------- *
* BE
* ---------------------------------------------------------------------------- *
u "$working_dataset/dataset_sampleBE_NOPGSparents_em.dta", clear
mark sample_1 if !missing(CogPGS, NCogPGS, mother_age, sex, yob, PC1, ///
PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10, Platform, pedu_max_0, N_child)
keep if sample_1 == 1
drop sample_1
foreach x of varlist CITO CogPGS NCogPGS {
egen `x'_sd = std(`x')
}
save "$working_dataset/BE_data_join.dta", replace
* ---------------------------------------------------------------------------- *
* WI
* ---------------------------------------------------------------------------- *
u "$working_dataset/dataset_sampleWT_randomsibling_em.dta", clear
mark sample_1 if !missing(CogPGS, NCogPGS, sex, yob, PC1, PC2, PC3, ///
PC4, PC5, PC6, PC7, PC8, PC9, PC10, Platform, pedu_max_0, N_child)
keep if sample_1== 1
drop sample_1
foreach x of varlist CITO CogPGS NCogPGS {
egen `x'_sd = std(`x')
}
save "$working_dataset/WI_data_join.dta", replace
* ---------------------------------------------------------------------------- *
* TRIO
* ---------------------------------------------------------------------------- *
u "$working_dataset/dataset_sampleBE_PGSparents_em.dta", clear
mark sample_1 if !missing(CogPGS, NCogPGS, sex, PC1, PC2, PC3, ///
PC4, PC5, PC6, PC7, PC8, PC9, PC10, Platform, pedu_max_0, N_child, ///
mother_age, yob, MCogPGS, FCogPGS, FNCogPGS, MNCogPGS)
keep if sample_1 == 1
drop sample_1
foreach x of varlist CITO CogPGS NCogPGS MCogPGS MNCogPGS FCogPGS FNCogPGS {
egen `x'_sd = std(`x')
}
save "$working_dataset/TRIO_data_join.dta", replace
********************************************************************************
* Multiple testing command
********************************************************************************
* ---------------------------------------------------------------------------- *
* Cognitive
* ---------------------------------------------------------------------------- *
* BE
use "$working_dataset/BE_data_join", clear
gen interaction = CogPGS_sd*pedu_max_0
#delimit ;
rwolf2 (reg rekenm7 CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsBE_mod_Cog_edumax , vce(cl FamilyNumber))
(reg taalm7 CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsBE_mod_Cog_edumax , vce(cl FamilyNumber))
(reg rekenm10 CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsBE_mod_Cog_edumax , vce(cl FamilyNumber))
(reg taalm10 CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsBE_mod_Cog_edumax , vce(cl FamilyNumber))
(reg CITO_sd CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsBE_mod_Cog_edumax , vce(cl FamilyNumber))
(reg track CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsBE_mod_Cog_edumax , vce(cl FamilyNumber))
(reg edu4_after1980 CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsBE_mod_Cog_edumax , vce(cl FamilyNumber)) ,
indepvars(interaction, interaction, interaction, interaction, interaction, interaction, interaction) reps(1000) seed(121316) nodots
;
#delimit cr
* WI
use "$working_dataset/WI_data_join", clear
gen interaction = CogPGS_sd*pedu_max_0
xtset FamilyNumber
#delimit ;
rwolf2 (xtreg rekenm7 CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsWI_mod_Cog_edumax
if dup_rekenm7==1 , fe vce(cl FamilyNumber))
(xtreg taalm7 CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsWI_mod_Cog_edumax
if dup_taalm7==1 , fe vce(cl FamilyNumber))
(xtreg rekenm10 CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsWI_mod_Cog_edumax
if dup_rekenm10==1 , fe vce(cl FamilyNumber))
(xtreg taalm10 CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsWI_mod_Cog_edumax
if dup_taalm10==1 , fe vce(cl FamilyNumber))
(xtreg CITO_sd CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsWI_mod_Cog_edumax
if dup_CITO_sd==1 , fe vce(cl FamilyNumber))
(xtreg track CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsWI_mod_Cog_edumax
if dup_track==1 , fe vce(cl FamilyNumber))
(xtreg edu4_after1980 CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsWI_mod_Cog_edumax
if dup_edu4_after1980==1 , fe vce(cl FamilyNumber)),
indepvars(interaction, interaction, interaction, interaction, interaction, interaction, interaction)
reps(1000) seed(121316) nodots
;
#delimit cr
* TRIO
use "$working_dataset/TRIO_data_join", clear
gen interaction = CogPGS_sd*pedu_max_0
#delimit ;
rwolf2 (reg rekenm7 CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsTRIO_mod_Cog_edumax , vce(cl FamilyNumber))
(reg taalm7 CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsTRIO_mod_Cog_edumax , vce(cl FamilyNumber))
(reg rekenm10 CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsTRIO_mod_Cog_edumax , vce(cl FamilyNumber))
(reg taalm10 CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsTRIO_mod_Cog_edumax , vce(cl FamilyNumber))
(reg CITO_sd CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsTRIO_mod_Cog_edumax , vce(cl FamilyNumber))
(reg track CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsTRIO_mod_Cog_edumax , vce(cl FamilyNumber))
(reg edu4_after1980 CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsTRIO_mod_Cog_edumax , vce(cl FamilyNumber)) ,
indepvars(interaction, interaction, interaction, interaction, interaction, interaction, interaction) reps(1000) seed(121316) nodots
;
#delimit cr
* ---------------------------------------------------------------------------- *
* Noncognitive
* ---------------------------------------------------------------------------- *
* BE
use "$working_dataset/BE_data_join", clear
gen interaction = NCogPGS_sd*pedu_max_0
#delimit ;
rwolf2 (reg rekenm7 CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsBE_mod_NCog_edumax , vce(cl FamilyNumber))
(reg taalm7 CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsBE_mod_NCog_edumax , vce(cl FamilyNumber))
(reg rekenm10 CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsBE_mod_NCog_edumax , vce(cl FamilyNumber))
(reg taalm10 CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsBE_mod_NCog_edumax , vce(cl FamilyNumber))
(reg CITO_sd CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsBE_mod_NCog_edumax , vce(cl FamilyNumber))
(reg track CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsBE_mod_NCog_edumax , vce(cl FamilyNumber))
(reg edu4_after1980 CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsBE_mod_NCog_edumax , vce(cl FamilyNumber)) ,
indepvars(interaction, interaction, interaction, interaction, interaction, interaction, interaction) reps(1000)
seed(121316) nodots
;
#delimit cr
* WI
use "$working_dataset/WI_data_join", clear
gen interaction = NCogPGS_sd*pedu_max_0
xtset FamilyNumber
#delimit ;
rwolf2 (xtreg rekenm7 CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsWI_mod_NCog_edumax
if dup_rekenm7==1 , fe vce(cl FamilyNumber))
(xtreg taalm7 CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsWI_mod_NCog_edumax
if dup_taalm7==1 , fe vce(cl FamilyNumber))
(xtreg rekenm10 CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsWI_mod_NCog_edumax
if dup_rekenm10==1 , fe vce(cl FamilyNumber))
(xtreg taalm10 CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsWI_mod_NCog_edumax
if dup_taalm10==1 , fe vce(cl FamilyNumber))
(xtreg CITO_sd CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsWI_mod_NCog_edumax
if dup_CITO_sd==1 , fe vce(cl FamilyNumber))
(xtreg track CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsWI_mod_NCog_edumax
if dup_track==1 , fe vce(cl FamilyNumber))
(xtreg edu4_after1980 CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsWI_mod_NCog_edumax
if dup_edu4_after1980==1 , fe vce(cl FamilyNumber)),
indepvars(interaction, interaction, interaction, interaction, interaction, interaction, interaction)
reps(1000) seed(121316) nodots
;
#delimit cr
* TRIO
use "$working_dataset/TRIO_data_join", clear
gen interaction = NCogPGS_sd*pedu_max_0
#delimit ;
rwolf2 (reg rekenm7 CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsTRIO_mod_NCog_edumax , vce(cl FamilyNumber))
(reg taalm7 CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsTRIO_mod_NCog_edumax , vce(cl FamilyNumber))
(reg rekenm10 CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsTRIO_mod_NCog_edumax , vce(cl FamilyNumber))
(reg taalm10 CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsTRIO_mod_NCog_edumax , vce(cl FamilyNumber))
(reg CITO_sd CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsTRIO_mod_NCog_edumax , vce(cl FamilyNumber))
(reg track CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsTRIO_mod_NCog_edumax , vce(cl FamilyNumber))
(reg edu4_after1980 CogPGS_sd NCogPGS_sd pedu_max_0 interaction $controlsTRIO_mod_NCog_edumax , vce(cl FamilyNumber)) ,
indepvars(interaction, interaction, interaction, interaction, interaction, interaction, interaction) reps(1000) seed(121316) nodots
;
#delimit cr